No registration required.
Welcome to the Sahlgrenska Academy Science Seminars, a series of seminars on Thursdays at 15-16. The seminars are conducted in Lecture Hall Arvid Carlsson at Academicum and online through zoom webinar.
Here is the link to the webinar: https://gu-se.zoom.us/j/65098393167
The seminars are open to anyone interested in taking part of scientific breakthroughs and projects in the medicine and health science field. Scientists, students and other staff from GU, VGR and other organisations with the common interest of medicine and health science, welcome!
Speaker: Professor Morag Park, McGill University, Canada
Although autophagy was initially considered a nonselective cellular process for bulk degradation, recent studies have highlighted how selective autophagy plays a crucial role in regulating cell biology. Autophagosome formation is dependent on the ATG8 family of proteins, which also play a key role in the recruitment of cargo into autophagic membranes. Although ATG8 is present as a single protein in yeast, in higher eukaryotes it has expanded to include several paralogs; LC3A, LC3B, LC3C, GABARAP, GABARAP-L1, and GABARAP-L2. This expansion is thought to provide increased flexibility and selectivity to autophagic responses. Among the LC3-family, LC3B is best studied and most widely used marker for autophagosomes, whereas LC3C is the member with the highest sequence divergence. By mapping the proximal interactome of ATG8-paralogs, LC3B and LC3C, we uncover a new LC3C-Endocytic-Associated-Pathway (LEAP) that recruits plasma membrane (PM) cargo, the Met RTK, and Transferrin R to autophagosomes. We provide mechanistic understanding of the LC3C interactome and LEAP dependent cargo degradation and how this may be altered and contribute to cancers.
Host: Kathrin Pfeifer, dep. of Biomedicine
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