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Morag Park: Selective signalling through autophagy

24
nov
2022
Organizer
Sahlgrenska Academy Science Seminars
Information and registration page
When and where?
15:00-16:00
Arvid Carlsson, Academicum, Medicinaregatan 3
Language
English

No registration required.

Welcome to the Sahlgrenska Academy Science Seminars, a series of seminars on Thursdays at 15-16. The seminars are conducted in Lecture Hall Arvid Carlsson at Academicum and online through zoom webinar.

Here is the link to the webinar: https://gu-se.zoom.us/j/65098393167

The seminars are open to anyone interested in taking part of scientific breakthroughs and projects in the medicine and health science field. Scientists, students and other staff from GU, VGR and other organisations with the common interest of medicine and health science, welcome!

Speaker: Professor Morag Park, McGill University, Canada

Topic:

Although autophagy was initially considered a nonselective cellular process for bulk degradation, recent studies have highlighted how selective autophagy plays a crucial role in regulating cell biology. Autophagosome formation is dependent on the ATG8 family of proteins, which also play a key role in the recruitment of cargo into autophagic membranes. Although ATG8 is present as a single protein in yeast, in higher eukaryotes it has expanded to include several paralogs; LC3A, LC3B, LC3C, GABARAP, GABARAP-L1, and GABARAP-L2. This expansion is thought to provide increased flexibility and selectivity to autophagic responses. Among the LC3-family, LC3B is best studied and most widely used marker for autophagosomes, whereas LC3C is the member with the highest sequence divergence. By mapping the proximal interactome of ATG8-paralogs, LC3B and LC3C, we uncover a new LC3C-Endocytic-Associated-Pathway (LEAP) that recruits plasma membrane (PM) cargo, the Met RTK, and Transferrin R to autophagosomes. We provide mechanistic understanding of the LC3C interactome and LEAP dependent cargo degradation and how this may be altered and contribute to cancers.

Welcome to our laboratory

Host: Kathrin Pfeifer, dep. of Biomedicine

 

Welcome!

 

Upcoming seminars

Flyer program Sahlgrenska Academy Science Seminars

 

Do you wish to sign up for an email reminder of the Sahlgrenska Science Seminars about one hour before it starts?

Send an email to research.support@sahlgrenska.gu.se

Topic: Reminder Sahlgrenska Academy Science Seminars

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Master’s and bachelor’s thesis fair in health and technology

Registration for supervisors
Last day to register: October 4th.

Pekka Katajisto: Role of the stem cell niche in aging

NOTE DAY AND TIME: on a Friday, 14:00H.

Hybrid meeting – in Lecture Hall Arvid Carlsson or online via Zoom.

  • Hybrid webinar 14:00-15:00, Monday September 22nd.
  • Link to Zoom webinar.
  • Sahlgrenska Academy Science Seminars – see full program in the Staff Portal.

Information from Sahlgrenska Academy Research Support Office

[UPDATED SEPTEMBER 20]
The Sahlgrenska Academy Research Support Office provides an overview of upcoming and current calls, nominations and events in an information letter. This letter is updated approximately four times per semester.

’20 minutes for researchers’ is back – see full autumn program

During 20 minutes over Zoom, the Biomedical Library gives tips on tools and services that can facilitate your research everyday life.

We are building at Medicinareberget

You will now find comprehensive information on construction projects that affect the Sahlgrenska Academy in the Staff Portal.

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