Akademiliv

Sahlgrenska akademins nyheter

På Svenska
University of Gothenburg Logotype
  • News
  • Notices
  • Grants
  • About Akademiliv

Fredrik Sterky has synapses on his mind

11 April, 2018

YOUNG RESEARCHERS. Fredrik Sterky is home in Gothenburg again after postgraduate studies in Stockholm and a postdoc at Stanford. He is a resident physician in clinical chemistry, with a research interest in the connections among nerve cells in the brain. He has research time in the Wallenberg Centre for Molecular and Translational Medicine (WCMTM) and was recently one of the few young researchers in Gothenburg who received establishment support in the Swedish Research Council’s call for proposals last year.

Although he comes from Gothenburg, he was not educated here. After upper-secondary school, he studied one year at the University of Arizona, where an enthusiastic chemistry professor aroused his interest in research.

“I had the opportunity to try working in his lab and discovered the exciting world of molecular building blocks.”

When it was time to do his 21-month internship after completing medical training in Uppsala, he began asking himself if he should give research a try. A bit by chance, he came in contact with Nils-Göran Larsson at Karolinska Institutet and began working in his lab on a project about mitochondria and Parkinson’s disease.

“I thought it was really great to be in an environment where you do experiments without knowing what they will produce. You might not get any meaningful results, but you may also obtain results that change the way we think about disease processes” says Fredrik.

His dissertation showed that Parkinson’s disease may be related to impaired function of mitochondria in neurons, by primarily affecting the synapses. During his clinical internship in Stockholm, he began thinking about doing a postdoc. He thought it would be easiest to persuade the family to accompany him to California for a few years, so when he had time off from the medical center, he went to Stanford practically for just over one day to meet renowned biochemist Thomas Südhof.

Thomas Südhof. Photo from Wikipedia Commons, by Juancamartos.

A prolonged celebration

When Fredrik Sterky and his family moved to Stanford in 2013, it turned out to be an eventful year for his new home laboratory. Fredrik barely had time to begin work as a postdoc on the team when Thomas Südhof was presented with the Lasker Award. The festive atmosphere at the lab had hardly settled down when it was announced that the team leader would also receive the Nobel Prize in 2013.

“It’s a large and successful lab, of course, and it was incredibly exciting to be able to come to Stanford and work with him,” says Fredrik.

Thomas Südhof is well-known for his studies of how brain cells communicate, which also became Fredrik’s research area. During his years as a postdoc, he began to study the mechanisms of how various neurons connect with synapses, which he is continuing to work on in Gothenburg.

Illustration av nervceller, sammankopplade med synapser.

“Among other things, we are investigating a group of proteins called neurexins, which sit on the surface of the synapses. They bind to other proteins on the receptor cell as a kind of molecular handshake. How this works – for example, how a neuron knows what other neurons it is to interconnect with – is only partially understood.”

A complex interaction

Neurexins help to recruit other proteins to the synapse, which defines the synapse’s properties.

“These proteins have been thoroughly studied, in part because mutations in the gene that encodes for neurexin-1 increase the risk for autism and schizophrenia,” Fredrik says.

During his time in Thomas Südhof’s lab, he found two new proteins that bind to the neurexins. Fredrik is now investigating the role these proteins play in the complex interaction of various proteins that regulate how synapses are formed and help to define their function.

Fredrik Sterky

“To understand the brain and the diseases that afflict the brain, we must first understand its building blocks. Today the most important players are known, but there is still much that we don’t know about how they interact with each other to mediate the function of neurons function,” says Fredrik.

The two proteins he found are known as CA10 and CA11. In an article in PNAS (Proceedings of the National Academy of Sciences), he showed recently that these proteins may interact with neurexins in an unexpected way:

“The binding of CA10 increases the synaptic levels of neurexins, at least in some circumstances, but the role of these proteins and their interactions with neurexins in the brain is still unknown.”

You can read more about Fredrik Sterky’s research team here: http://wcmtm.gu.se/research-groups/sterky

TEXT: ELIN LINDSTRÖM CLAESSEN
PORTRAIT PHOTO OF FREDRIK STERKY: JOHAN WINGBORG

 

 

 

 

By: Elin Lindström
Tagged With: institutionen för biomedicin, Sahlgrenska Universitetssjukhuset

HAPPY SUMMER!

The newsletter from Akademiliv will return on Wednesday, August 21st.

Contact your institute to add your event to the calendar in the Staff Portal

  • Biomedicine: Kristian Kvint: kalender@biomedicine.gu.se
  • Core Facilities: Amelie Karlsson: amelie.karlsson.2@gu.se
  • Clinical Sciences: Katarina Olinder Eriksson: klinvet@gu.se
  • Medicine: Nina Raun; kommunikation@medicine.gu.se
  • Neuroscience and Physiology: Josefin Bergenholtz; kommunikation@neuro.gu.se
  • Odontology: Johan Thompson; info@odontologi.gu.se
  • Sahlgrenska Academy’s Office and faculty-wide calendar events Åsa Ekvall; info@sahlgrenska.gu.se
  • Health and Care Sciences: Karin Mossberg; vardvetenskap@fhs.gu.se

Information from Sahlgrenska Academy Research Support Office

[UPDATED JUNE 2024]
The Sahlgrenska Academy Research Support Office provides an overview of upcoming and current calls, nominations and events in an information letter. This letter is updated on a monthly basis.
Current and previous newsletters are also available in the Staff Portal.

’20 minutes for researchers’ is back – see full spring program

During 20 minutes over Zoom, the Biomedical Library gives tips on tools and services that can facilitate your research everyday life.

More news

En personlig död (A Personal Death) – a chance to win Björn Fagerberg’s new book

27 May, 2024

NEW BOOK. During his career as a physician specializing in internal medicine, Björn Fagerberg has been involved in many end-of-life situations, …  

She is doing her residency in the US with a medical degree from Gothenburg

21 May, 2024

STUDENT. Doing a “residency” in orthopedics in the United States is an unattainable dream for many newly qualified American doctors. Now Janina Ka …  

Alba Corell reports from a high-level brain tumor meeting

20 May, 2024

COLUMN. The recent gathering of the Scandinavian Society of Neuro-oncology (SNOG) in Gothenburg has concluded. Professor Asgeir Jakola hosted and …  

From South Africa to Sweden: Collaborative Research Efforts Improving Pregnant Women’s Health

17 May, 2024

GLOBAL HEALTH. In the bustling Tygerberg University Hospital in Cape Town, a dedicated research team led by Lina Bergman, is on a mission to …  

Sara Bjursten and Anna Wenger are the recipients of the Assar Gabrielsson Prize 2024

17 May, 2024

AWARD. The Assar Gabrielsson Foundation has named Anna Wenger as the winner in the basic science research category and Sara Bjursten as the …  

A full day for PhD students focused on mental health

16 May, 2024

PHD STUDENTS. For the sixth time, PhD students at Sahlgrenska Academy were invited to PhD Day, organized by the Doctoral Student Council. The day …  

Kaj Blennow ranked highest in Sweden in neuroscience

16 May, 2024

AWARD. In this year's edition of the researcher ranking from Research.com in the field of neuroscience, Kaj Blennow is ranked 17th …  

Linda Wass is doing a postdoc at Stanford with ALF funding

14 May, 2024

ALF FUNDING. Biomedical Scientist Linda Wass has just settled in Stanford, California, where she will spend two years as a postdoc. She is the …  

Karin Nilsson wrote the Thesis of the Year at Sahlgrenska Academy in 2023

14 May, 2024

AWARD. Karin Nilsson, currently a postdoc at the Department of Internal Medicine and Clinical Nutrition, receives the faculty-wide Thesis of the …  

Some answers from the proposed members of the next Faculty Board

14 May, 2024

FACULTY ELECTIONS. The eight proposed members of the next Faculty Board hereby give some brief answers on how they want to contribute to the work …  

More news...

Sahlgrenska Academy

© University of Gothenburg
PO-Box 100, S-405 30 Gothenburg, Sweden
Phone: 00 46 31 786 0000

About the website

Elin Lindström is editor for Akademiliv.
Please feel free to send your ideas and comments to akademiliv@gu.se

Sign up for the Akademiliv newsletter:

Send you tips to Akademiliv

Do you have a suggestion for news, grants, seminars or an education?
Send an email to Elin Lindström Claessen