Akademiliv

Sahlgrenska akademins nyheter

På Svenska
University of Gothenburg Logotype
  • News
  • Notices
  • Grants
  • About Akademiliv

Higher doses of antidepressants are associated with better treatment response

20 June, 2016

NEW STUDY. In contrast to what has previously been claimed, low doses of antidepressants are clearly less effective than higher ones. This is the principal finding of a new study from the Sahlgrenska Academy at the University of Gothenburg in Sweden. The authors also suggest that antidepressants, when used at an optimal dose, are considerably more effective than usually assumed.

Selective serotonin reuptake inhibitors, or SSRIs, are antidepressants influencing the activity of the neurotransmitter serotonin. While the SSRIs remain the most commonly prescribed type of antidepressant, it has recently been questioned if these drugs actually display any antidepressant effect.

“It has never been convincingly shown that higher doses of SSRIs are more effective than lower ones and this alleged lack of dose-response has often been put forward as an argument for the view that they do not display any specific, pharmacological antidepressant action”, says Fredrik Hieronymus, PhD student in pharmacology at Sahlgrenska Academy, University of Gothenburg.

Three common SSRIs

In their analysis the researchers included all clinical trials in adult major depression conducted by the manufacturers of three common SSRIs where predefined doses were compared to placebo. In total the analysis comprises close to 3000 patients from eleven clinical studies, including all relevant studies for the SSRIs citalopram (Celexa™), sertraline (Zoloft™), and paroxetine (Paxil™).

“We find that low but commonly used doses of SSRIs are more effective than placebo but clearly less effective than higher doses. We did not, however, detect any additional improvement in patients that received what might be regarded as very high doses”, relates Fredrik Hieronymus.

Higher effect

When the scientists excluded those patients that had received suboptimal doses from the analysis, the antidepressant effect of the studied SSRIs turned out to be markedly higher than what has previously been suggested.

“One has tended to disregard the possible influence of dose in earlier assessments of these drugs, hence including suboptimal doses in the analyses, which we suggest has led to an underestimation of their efficacy”, says Fredrik Hieronymus, however adding that their results do not support the use of the highest recommended doses:

“For the individual patient, the choice of dose must be guided not only by the antidepressant response but also by possible side effects.”

Early effect

The study also reveals that the SSRIs are significantly superior to placebo already after one week of treatment, which is in contrast with the conventional wisdom that the beneficial effects are not apparent until the treatment has been in effect for a couple of weeks.

“It does take several weeks for the full effect of the treatment to appear”, states Fredrik Hieronymus, “but the fact that there is a modest but significant decrease in depressed mood in many patients already after the first week of treatment is of theoretical interest and may be of importance when trying to clarify why drugs affecting serotonin yields an antidepressant response”.

The article, A mega-analysis of fixed-dose trials reveals a dose-dependency and a rapid onset of action for the antidepressant effect of three selective serotonin reuptake inhibitors, is published in the journal Translational Psychiatry.

Link to article

By: Elin Lindström
Tagged With: institutionen för neurovetenskap och fysiologi

HAPPY SUMMER!

The newsletter from Akademiliv will return on Wednesday, August 21st.

Contact your institute to add your event to the calendar in the Staff Portal

  • Biomedicine: Kristian Kvint: kalender@biomedicine.gu.se
  • Core Facilities: Amelie Karlsson: amelie.karlsson.2@gu.se
  • Clinical Sciences: Katarina Olinder Eriksson: klinvet@gu.se
  • Medicine: Nina Raun; kommunikation@medicine.gu.se
  • Neuroscience and Physiology: Josefin Bergenholtz; kommunikation@neuro.gu.se
  • Odontology: Johan Thompson; info@odontologi.gu.se
  • Sahlgrenska Academy’s Office and faculty-wide calendar events Åsa Ekvall; info@sahlgrenska.gu.se
  • Health and Care Sciences: Karin Mossberg; vardvetenskap@fhs.gu.se

Information from Sahlgrenska Academy Research Support Office

[UPDATED JUNE 2024]
The Sahlgrenska Academy Research Support Office provides an overview of upcoming and current calls, nominations and events in an information letter. This letter is updated on a monthly basis.
Current and previous newsletters are also available in the Staff Portal.

’20 minutes for researchers’ is back – see full spring program

During 20 minutes over Zoom, the Biomedical Library gives tips on tools and services that can facilitate your research everyday life.

More news

En personlig död (A Personal Death) – a chance to win Björn Fagerberg’s new book

27 May, 2024

NEW BOOK. During his career as a physician specializing in internal medicine, Björn Fagerberg has been involved in many end-of-life situations, …  

She is doing her residency in the US with a medical degree from Gothenburg

21 May, 2024

STUDENT. Doing a “residency” in orthopedics in the United States is an unattainable dream for many newly qualified American doctors. Now Janina Ka …  

Alba Corell reports from a high-level brain tumor meeting

20 May, 2024

COLUMN. The recent gathering of the Scandinavian Society of Neuro-oncology (SNOG) in Gothenburg has concluded. Professor Asgeir Jakola hosted and …  

From South Africa to Sweden: Collaborative Research Efforts Improving Pregnant Women’s Health

17 May, 2024

GLOBAL HEALTH. In the bustling Tygerberg University Hospital in Cape Town, a dedicated research team led by Lina Bergman, is on a mission to …  

Sara Bjursten and Anna Wenger are the recipients of the Assar Gabrielsson Prize 2024

17 May, 2024

AWARD. The Assar Gabrielsson Foundation has named Anna Wenger as the winner in the basic science research category and Sara Bjursten as the …  

A full day for PhD students focused on mental health

16 May, 2024

PHD STUDENTS. For the sixth time, PhD students at Sahlgrenska Academy were invited to PhD Day, organized by the Doctoral Student Council. The day …  

Kaj Blennow ranked highest in Sweden in neuroscience

16 May, 2024

AWARD. In this year's edition of the researcher ranking from Research.com in the field of neuroscience, Kaj Blennow is ranked 17th …  

Linda Wass is doing a postdoc at Stanford with ALF funding

14 May, 2024

ALF FUNDING. Biomedical Scientist Linda Wass has just settled in Stanford, California, where she will spend two years as a postdoc. She is the …  

Karin Nilsson wrote the Thesis of the Year at Sahlgrenska Academy in 2023

14 May, 2024

AWARD. Karin Nilsson, currently a postdoc at the Department of Internal Medicine and Clinical Nutrition, receives the faculty-wide Thesis of the …  

Some answers from the proposed members of the next Faculty Board

14 May, 2024

FACULTY ELECTIONS. The eight proposed members of the next Faculty Board hereby give some brief answers on how they want to contribute to the work …  

More news...

Sahlgrenska Academy

© University of Gothenburg
PO-Box 100, S-405 30 Gothenburg, Sweden
Phone: 00 46 31 786 0000

About the website

Elin Lindström is editor for Akademiliv.
Please feel free to send your ideas and comments to akademiliv@gu.se

Sign up for the Akademiliv newsletter:

Send you tips to Akademiliv

Do you have a suggestion for news, grants, seminars or an education?
Send an email to Elin Lindström Claessen