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Volkan Sayin has been awarded SEK 2.4 million from the Swedish Cancer Society. His project is about a platform for defining tumor-specific metabolic Achilles heels for individualized treatment of KRAS-driven non-small cell lung cancer. (Photo: Johan Wingborg)

A total of almost SEK 70 million from the Swedish Cancer Society

20 November, 2020

GRANTS. Twenty-seven researchers at the University of Gothenburg have together received just over SEK 68 million for various research projects from the Swedish Cancer Society.

Claes Gustafsson, a professor at the Institute of Biomedicine, has received SEK 6 million over three years for his project, where he hopes to create a solid biochemical understanding of how the genome is expressed in mitochondria, the part in the cell that produces the cell’s energy. Over the long term, this research can contribute to the development of new types of cancer drugs.

The role of mitochondria in cancer

Since cancer cells often use glycolysis to produce the energy molecule ATP, mitochondria were previously not considered to play a significant role in cancer, but that view has changed, says Gustafsson.

Claes Gustafsson.

“In addition to their central role in creating ATP, the mitochondria are needed for several other functions, such as creating building blocks for various cellular synthesis pathways and regulating calcium levels in the cell. Substances that inhibit various aspects of mitochondrial function are already in clinical trials.”

Radioactive drugs

Eva Forssell-Aronsson, professor of radiation physics, has received SEK 5.25 million divided over three years. She is leading a project where researchers will try to find new methods to treat incurable tumor diseases with the help of radioactive drugs that look for cancer cells in the body and radiate them in situ.

Eva Forssell-Aronsson.

“Radioactive drugs have the potential to reach cancer cells throughout the body, making them particularly suitable for cancer that has spread and where it is unknown exactly where in the body the cancer cells are located,” says Forssell-Aronsson. “We will study cancer of the gastrointestinal tract, thyroid gland and breast tissue. In particular, we are working to be able to cure patients with neuroendocrine tumors, where today it is difficult to remove the tumor tissue without damaging healthy organs.”

Read the complete list of grant recipients on the Swedish Cancer Society’s website: https://static-files.cancerfonden.se/forskningsnamndens-beslut-nov-2020.pdf

 

RESEARCH MONTHS

Anne Thilander Klang
Framtagning av nya metoder för förbättradstrålbehandling baserad på avancerad dubbelenergi datortomografi (DECT)
Three research months per year for three years.

PROJECTS

Annica Almståhl
Utvärdering av ett munvårdsprogram för patienter som genomgår behandling av huvud- och halscancer beträffande mukosit, munhälsa, patientrelaterade faktorer, livskvalitet och hälsoekonomi
1 200 000 kronor

Changyan Chen
Återanvändning av läkemedel som strategi för att utveckla ny behandling mot bukspottkörtelcancer
1 800 000 kronor

Pernilla Dahm Kähler
Mot Excellens-baserad Gynekologisk Cancervård
1 200 000 kronor

Eva Forssell Aronsson
Radionuklidterapi av endokrina tumörer och bröstcancer: Nya behandlingsstrategier, och ny kunskap om mekanismer och biomarkörer förbehandlingssvar
5 250 000 kronor

Bengt Gustafsson
En translationell ansats för att identifiera biomarkörer som förutsäger utfall och behandlingsrelaterad toxicitet vid kolorektal cancer
1 600 000 kronor

Claes Gustafsson
Mitokondriell biogenes som mål för cancerbehandling
6 000 0000 kronor

Ola Hammarsten
Att hitta de mest känsliga inför cancerterapi medstrålning och cytostatika
2 400 000 kronor

Khalil Helou
Nya prognostiska och prediktiva biomarkörer för beslut om behandling av äggstockscancer
2 400 000 kronor

Jonas Hugosson
”The Göteborg-2 trial”; En prospektiv, randomiserad, befolkningsbaserad studie av screening av prostatacancer med prostataspecifikt antigen (PSA) test följt av magnetisk resonanstomografi (MRI) av prostata.
6 000 000 kronor

Martin Johansson
Studier av den exceptionella metabolismen av njurcellskarcinom
1 000 000 kronor

Per Lindahl
Ett CRISPR-Cas9-tillvägagångssätt för att utveckla pro-oxidantterapier vid lungcancer
2 400 000 kronor

Magnus Lindh
Virala och chimära transkript i levervävnad med eller utan cancer vid kronisk hepatit B-virusinfektion
2 400 000 kronor

Per Lindnér
Levertransplantation som behandling av levermetastaserad kolorektal cancer (SOULMATE-studien).
2 400 000 kronor

Kent Lundholm
Förebyggande av muskelavfall efter större cancerkirurgi för förbättrad organ- och fysisk funktion.
1 600 000 kronor

Jan Olof Lötvall
En ny form av exosombaserad cancerimmunterapi – som gör kalla tumörer heta
3 000 000 kronor

Stephan Maier
Artificiell intelligens för reproducerbar MR-diagnos av prostatacancer
2 400 000 kronor

Tommy Martinsson
Neuroblastom, identifiering av terapeutiska mål för en speciellt svårbotad grupp.
1 600 000 kronor

Mikael Nilsson
Musmodellering av sporadisk utveckling av sköldkörtelcancer
2 500 000 kronor

Lars Palmqvist
Molekylära mekanismer vid utveckling av akut myeloisk leukemi
3 000 000 kronor

Johan Ruud
Cancerutlöst aptit- och viktförlust: ny krets, ny mekanism
2 400 000 kronor

Volkan Sayin
En plattform för att definiera tumörspecifika metabola akilleshälar för individanpassad behandling av KRAS-driven icke-småcellig lungcancer
2 400 000 kronor

Giovanni Solinas
Resolving the Role of Specific Phosphoinositide 3-kinases (PI3Ks) Isoforms in Metabolism-Insulin Loops Driving Tumor-Promotion
3 000 000 kronor

Ulf Strömberg
Utveckling av geomapping för analyser och monitorering av ojämlikheter i tidig upptäckt av cancer inom hela Sverige
2 400 000 kronor

Susanne Teneberg
Helicobacter pylori och magcancer: Rollen av kolhydratreceptorer i H. pylori-inducerad inflammation
1 200 000 kronor

Karin Welén
Molekylär karaktärisering av metastaserad prostatacancer -från metastasmekanismer till klinisk nytta
2 400 000 kronor

Changlian Zhu
Förebyggande av strålningsinducerade kognitiva brister med sen början i den unga hjärnan
3 000 000 kronor

Pierre Åman
FET-gruppen av fusionsonkogener – transformationsmekanismer, epigenetik och terapiförsök
1 200 000 kronor

PLANNING GROUP

Eva Forssell Aronsson
Planeringsgruppen för Onkologisk radionuklidterapi (POR)
450 000 kronor

 

By: Elin Lindström

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