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Petronella Kettunen to recieve funding from the Torsten Söderberg Foundation.

25 March, 2013

MODEL. Zebrafish is used as animal model in dementia research at the Sahlgrenska Academy.
MODEL. Zebrafish is used as animal model in dementia research at the Sahlgrenska Academy.

Can zebrafish provide the key to new treatments for Alzheimer’s disease? Petronella Kettunen hopes so. She will now receive SEK 1.75 million from the Torsten Söderberg Foundation for a unique research project.

Petronella Kettunen
Petronella Kettunen

Petronella Kettunen at the Institute of Neuroscience and Physiology, Sahlgrenska Academy, has developed a new model in which zebrafish is used to study Alzheimer’s disease. The purpose of the studies is to better understand the disease – but the zebrafish model will also be used to test future drugs against Alzheimer’s disease.

Following fluorescent cells
Petronella Kettunen will now receive SEK 1 750 000 from the Torsten Söderberg Foundation to study the causes of memory problems.
– Right now we are working to investigate how a particular molecule called Abeta leads to memory loss and degradation of nerve cells in zebra fish fry. We use transgenic fish with luminous cells, which allows us to observe them under a microscope, says Petronella Kettunen.
-By filming accumulation of Abeta molecule in the fish brain, we can study how the brain’s immune cells break down Abeta, and then test the fish memory to see how it is affected by degradation.
Increase knowledge about Alzheimer’s
The hope is that the new zebrafish model will contribute to new knowledge about how Alzheimer’s disease prevents the formation of new memories, and how the body’s own immune processes can possibly be used to protect against the disease progress.

A total of four researchers at the Sahlgrenska Academy receive grants from the Foundation this call. Besides Petronella Kettunen, Gunnar C. Hansson receives SEK two million for his research on defects in the colon inner mucus layer in ulcerative colitis, Kristina Eriksson gets a million and a half for her project about how the natural immune system of the placenta and the newborn works at a viral infection, and Jan-Åke Liljeqvist gets SEK three million in the development of vaccines against herpes simplex virus type 2 infection.

By: Elin Lindström
Tagged With: External research grants

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