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Welcome to the Sahlgrenska Academy Science Seminars, a series of seminars on Thursdays at 15-16. The seminars are, during early Autumn 2021, conducted through Zoom Meetings until the end of October. Thereafter they will be conducted both physical in Arvid Carlsson lecture hall at Academicum and online through zoom.
The seminars are open to anyone interested in taking part of scientific breakthroughs and projects in the medicine and health science field. Scientists, students and other staff from GU, VGR and other organisations with the common interest of medicine and health science, welcome!
Speaker: Anders Ståhlberg, Dep. of Biomedicine, GU
Topic: Screening of liquid biopsy free DNA in detection and monitoring cancer
Currently, it is challenging to monitor treatment efficacy and at an early stage detect relapse and/or metastasis in cancers. Repeated tissue biopsies are both invasive and usually not feasible, particularly if no tumor is radiologically evident. Imaging techniques are golden standard, but would clearly benefit from complementary analysis that provide increased detection rate, optimized timing of imaging and molecular information about disease and treatment. Ultrasensitive analysis of nucleic acids in blood addresses these issues. We have developed SiMSen-Seq that is suitable to detect individual nucleotide changes in DNA and RNA molecules. The approach is applied to detect low mutant allele frequencies in cell-free nucleic acids as well as profiling immune cell repertoires. We are currently implementing our approach in a clinical setting, including the entire workflow from sampling, logistics, preanalytical steps, SiMSen-Seq, bioinformactics and clinical reports. Our approach is generic for most solid tumor entities and can also be applied to applications beyond cancer. We will present data from several ongoing projects and applications, demonstrating the clinical potential of ultrasensitive nucleic acids analysis using minimally invasive liquid biopsies.
Anders Ståhlberg, Associate Professor at the Sahlgrenska Center for Cancer Research, University of Gothenburg and at Clinical Genetics and Genomics, Sahlgrenska University Hospital in Sweden. Anders primary research interest is to identify and define molecular mechanisms in tumor development and to develop and clinically implement liquid-based diagnostics. His basic research is focused on sarcomas, including pediatric sarcomas. In the cancer diagnostics, he is working with a wider spectrum of tumor entities and applications areas utilizing minimally invasive sampling. Anders has developed several strategies for gene expression profiling and rare molecule analysis, especially at the single-cell and single-molecule level. Research homepage:
Host: Pierre Åman
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