Johan Sandberg: Human MAIT cells in health and viral disease

No registration required.

Welcome to the Sahlgrenska Academy Science Seminars, a series of seminars on Thursdays at 15-16. This seminar will be conducted in Lecture Hall Arvid Carlsson at Academicum and online through zoom webinar.

Here is the link to the webinar: https://gu-se.zoom.us/j/69062201519

The seminars are open to anyone interested in taking part of scientific breakthroughs and projects in the medicine and health science field. Scientists, students and other staff from GU, VGR and other organisations with the common interest of medicine and health science, welcome!

Speaker: Johan Sandberg, KI

Topic:

Mucosa-associated invariant T (MAIT) cells are a large subset of unconventional, innate-like T cells that are highly abundant in mucosal tissues, liver and peripheral blood. MAIT cells recognize microbial riboflavin metabolites from a wide range of microbes presented by the highly evolutionarily conserved and non-polymorphic MHC class I-like MR1 molecules. MAIT cells thus represent an arm of cell-mediated antibacterial immunity which recognize a conserved type of antigenic structure. Furthermore, recent findings indicate that MAIT cells also play important roles in viral infections, inflammation, as well as in tissue repair. Nevertheless, many aspects of MAIT cell immunobiology and role in infectious diseases remain unexplored. This talk will cover recent findings from our lab regarding the functional specialization of human MAIT cell subsets in tissues as well as their involvement in COVID-19 immunopathogenesis.

Host: Marianne Quiding Järbrink, Dep. of Biomedicine

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