okt
2021
Online
No registration required.
Welcome to the Sahlgrenska Academy Science Seminars, a series of seminars on Thursdays at 15-16. The seminars are, during early Autumn 2021, conducted through Zoom Meetings until the end of October. Thereafter they will be conducted both physical in Arvid Carlsson lecture hall at Academicum and online through zoom.
The seminars are open to anyone interested in taking part of scientific breakthroughs and projects in the medicine and health science field. Scientists, students and other staff from GU, VGR and other organisations with the common interest of medicine and health science, welcome!
Here is the link to the webinar: https://gu-se.zoom.us/j/61457198449
Speaker: Carolina Guibentif, Dep. of Biomedicine, GU
Topic: Single-Cell Genomics of Human Development – Towards in vitro preclinical models of childhood cancer
The Guibentif group is focused on understanding prenatal events leading to childhood leukaemia. Half of all childhood cancers have a suspected prenatal origin, which limits access to the cancer-initiating developmental progenitor. Human pluripotent stem cells (hPSCs) can be differentiated in vitro, mimicking defined processes of embryonic development, and thus represent a promising tool to dissect the molecular mechanisms of malignant transformation taking place in prenatal cell populations. Haematological malignancies constitute a particular challenge, as the hematopoietic system develops through successive waves, in multiple anatomical locations and embryonic developmental time-points. The molecular mechanisms regulating the emergence and specialization of these successive embryonic blood progenitors are currently a topic of investigation in the group. The also study the relation between developmental processes leading to blood formation during hPSC differentiation vs corresponding blood waves in the embryo. The Guibentif group employs a cross-species approach, harnessing single-cell profiling technology, to bridge hPSC-based in vitro models of human embryonic development with the latest progress in developmental haematopoiesis studied in vivo in the mouse. Their goal is to chart the diversity of hematopoietic waves occurring in vitro, in order to identify and characterize the developmental populations susceptible to transformation that lead to childhood leukaemia.
Host: Ruth Palmer
Welcome!
Upcoming seminars and downloadable program
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Topic: Reminder Sahlgrenska Academy Science Seminars