No registration needed.
Speaker: Dr. Marcelo A. Mori, Affiliated Member of the Brazilian Academy of Sciences, Head of the Department of Biochemistry and Tissue Biology, University of Campinas; Assistant Professor of Biology of Aging in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Brazil.
Local host: Dr. Muhammad Nawaz, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg.
Sahlgrenska Academy Seminars is a seminar series initiated by The Council for Research (FOR). The seminar series aim to promote scientific exchange between scientists at Sahlgrenska Academy and prominent international scientists and universities, and to increase the opportunities for informal scientific discussions and interactions between faculty members and students at our faculty.
Lab web page: https://morilab.wixsite.com/morilab
miRNAs biogenesis decreases with aging in multiple tissues particularly in adipose tissue of mammals and in the intestine of C. elegans. In contrast, dietary restriction reverses these patterns
Overall miRNA biogenesis decreases in adipose tissue, in part due to a downregulation of the type III endoribonuclease DICER, which is evident in adipose tissue of mammals and in the intestine of C. elegans. Dr. Marcelo’s Lab has been investigating the molecular mechanisms underlying the changes in miRNA biogenesis with aging and dietary restriction in species such as worms, flies, mice and humans and has revealed the pathways with several aspects of the aging process including the control of redox balance, energy utilization and long distance inter-tissue communication. In addition, his Lab has proposed pharmacological strategies to promote miRNA biogenesis in order to prolong health span.
Dr. Marcelo A. Mori, did his PhD from Brazil (2007), and also had an exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). He has been a Postdoctoral fellow at Joslin Diabetes Center / Harvard Medical School (Boston, USA). Dr. Marcelo served as Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently, he is head of department and Assistant Professor of Biology of Aging in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas. He is also an Affiliated Member of the Brazilian Academy of Sciences. His expertise are in the area of Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process.